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KMID : 0356919690020010021
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Korean Journal of Anesthesiology
1969 Volume.2 No. 1 p.21 ~ p.27
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Effect of Alpha Adrenergic Blocking Agent on Cyclopropane-Epinephrine Cardiac Arrhythmia in Dogs
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Abstract
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1) Cardiac arrhythmias were produced in 8 mongrel dogs (weight, 13.3 ±1.5 kg) by injections of
epinephrine (0.032±0.0302 mg/kg) during inhalation of 25 per cent cyclopropane in oxygen.
2) Femoral arterial pressure was measured with a Statham transducer, and Lead I of the electrocardio-
gram recorded on a Sanborn Twin-Viso at a paper speed of 25 mm/sec.
3) Regitine (0.47±0.19 mg/kg), an alpha adrenergic blocking agent, significantly decreased the pressor response to epinephrine and consistently increased (4.8±1.8 times) the individual threshold doses of epinephrine required to produce cardiac arrhythmias.
4) In most instances the protective result was attributable to a modification by Regitine of the pressor effect of epinephrine.
5) It is concluded in the light that cyclopropane-epinephrine cardiac arrhythmias are blocked by alpha adrenergic blockade.
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